Gregory Hannon

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Greg Hannon
FRS FMedSci
Born Gregory James Hannon[1]
1964 (age 59–60)[2]
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Institutions University of Cambridge
New York Genome Center
Cold Spring Harbor Laboratory
Howard Hughes Medical Institute[4]
Alma mater Case Western Reserve University (BA, PhD)[5]
Thesis Trans-splicing of nematode pre-messenger RNA (1992)
Doctoral advisor Timothy W. Nilsen[6]
Doctoral students Emily Bernstein
Other notable students Lin He (postdoc)
Influences Simon Tavaré[7]
Shankar Balasubramanian[7]
Notable awards EMBO Member (2018)[8]
Royal Society Wolfson Research Merit Award (2015)[9]
Website
hannonlab.org

Gregory James Hannon FRS FMedSci [10] (born 1964) is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Institute at the University of Cambridge.[5] He is a Fellow of Trinity College, Cambridge[11][12] while also serving as a director of cancer genomics at the New York Genome Center[13] and an adjunct professor at Cold Spring Harbor Laboratory.[14]

Career and research

Hannon is known for his contributions to small RNA biology, cancer biology, and mammalian genomics.[10][3][15][16] He has a history in discovery of oncogenes, beginning with work that led to the identification of CDK inhibitors and their links to cancer.[10] More recently, his work has focused on small RNA biology, which led to an understanding of the biochemical mechanisms and biological functions of RNA interference (RNAi).[17][18][10] He has developed widely used tools and strategies for manipulation of gene expression in mammalian cells and animals and has generated genome-wide short hairpin RNA (shRNA) libraries that are available to the cancer community and was among the first to demonstrate roles for microRNAs in cancer.[10][19] His laboratory also discovered the piwi-interacting RNA (piRNA) pathway and linked this to transposon repression and the protection of germ cell genomes.[10] His innovations include the development of selective re-sequencing strategies, broadly termed exome capture.[10]

In 2017, Hannon was awarded a £20 million Cancer Grand Challenges[20] award to unite the IMAXT team - a team of researchers from Switzerland, Ireland, Canada, the USA and the UK, with far ranging expertise from cancer biology and pathology to astronomy and even VR video game design. The team's aim is to create an interactive 3D map of cancer, which could be explored in virtual reality.[21][22] The programme could transform the way researchers study cancer by providing unprecedented insight into how individual cells are arranged and how they interact to allow the tumour to grow.[23][24]

In 2018, it was announced Prof Hannon would guide the Functional Genomics Centre, a collaboration between Cancer Research UK and AstraZeneca.[25] The centre, housed inside the Milner Therapeutics Institute, aims to act as a hub for genetic screens, cancer models, CRISPR tool design, and computational approaches to big data to understand genetic changes in cancer development and identify potential drug targets.[24][26]

Awards and honours

References

  1. ↑ Greg Hannon's Entry at ORCID
  2. ↑ Gregory Hannon at Library of Congress Authorities, with {{{3}}} catalog{{{4}}} records
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gregory Hannon at Google Scholar
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Lua error in package.lua at line 80: module 'strict' not found. One or more of the preceding sentences incorporates text from the royalsociety.org website where: <templatestyles src="Template:Blockquote/styles.css" />

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  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  14. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  15. ↑ Gregory Hannon publications indexed by the Scopus bibliographic database. (subscription required)
  16. ↑ Gregory Hannon publications from Europe PubMed Central
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found. Closed access
  18. ↑ Lua error in package.lua at line 80: module 'strict' not found. Closed access
  19. ↑ Lua error in package.lua at line 80: module 'strict' not found. Closed access
  20. ↑ cancergrandchallenges.org/teams/imaxt
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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