WWC1

WW and C2 domain containing 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Z0U
Identifiers
Symbols	WWC1 ; HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168
External IDs	OMIM: 610533 MGI: 2388637 HomoloGene: 69180 GeneCards: WWC1 Gene
Gene ontology Molecular function • transcription coactivator activity • protein binding • kinase binding • protein binding, bridging • protein complex scaffold Cellular component • nucleus • cytoplasm • cytosol • ruffle membrane • protein complex • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • cell migration • establishment of cell polarity • regulation of intracellular transport • hippo signaling • regulation of hippo signaling • negative regulation of hippo signaling • positive regulation of MAPK cascade • negative regulation of organ growth Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23286	211652
Ensembl	ENSG00000113645	ENSMUSG00000018849
UniProt	Q8IX03	Q5SXA9
RefSeq (mRNA)	NM_001161661	NM_170779
RefSeq (protein)	NP_001155133	NP_740749
Location (UCSC)	Chr 5: 168.29 – 168.47 Mb	Chr 11: 35.84 – 35.98 Mb
PubMed search	[1]	[2]

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

A single nucleotide polymorphism (rs17070145) in the gene has been association with human memory performance in one 2006 study. No significant support for association with memory was found in a study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.

Studies have also begun to investigate the role of KIBRA in Alzheimer's disease.

Interactions

KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity. For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation. KIBRA has been shown to interact with Protein kinase Mζ.

External links

• Division of Cognitive Neuroscience, University of Basel, Switzerland