N-acetyltransferase 2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.[1]
Function
This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.[2]
Phenotype prediction
The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).[3][4][5][6]
References
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<references />, or <references group="..." />Further reading
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External links
- NAT2 human gene location in the UCSC Genome Browser.
- NAT2 human gene details in the UCSC Genome Browser.
- Template:The Arylamine N-acetyltransferase Gene Nomenclature Committee homepage: http://nat.mbg.duth.gr/
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