Transition (genetics)
<templatestyles src="Module:Hatnote/styles.css"></templatestyles>
In genetics, a transition is a point mutation that changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.[1]
Transitions can be caused by oxidative deamination and tautomerization.[2] Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.[3]
5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous deamination. This mechanism is important because it dictates the rarity of CpG islands.
See also
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references> tag; parameter "group" is allowed only.
<references />, or <references group="..." />External links
 |
Wikimedia Commons has media related to Transition (genetics). |
<templatestyles src="Asbox/styles.css"></templatestyles>
 |
This cell biology article is a stub. You can help Wikipedia by expanding it. |
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Mutations & Mutagenesis
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
