Acedapsone

Acedapsone

Skeletal formula of acedapsone
Space-filling model of the acedapsone molecule
Systematic (IUPAC) name
N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
Clinical data
Trade names	Rodilone Hansolar
Identifiers
CAS Number	77-46-3 N
ATC code	none
PubChem	CID: 6477
ChemSpider	6232 Y
UNII	0GZ72U84TN Y
KEGG	D02751 Y
ChEMBL	CHEMBL154166 Y
Chemical data
Formula	C16H16N2O4S
Molecular mass	332.374 g/mol
SMILES CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C
InChI InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20) Y Key:AMTPYFGPPVFBBI-UHFFFAOYSA-N Y
Physical data
Melting point	290 °C (554 °F)
NY (what is this?)  (verify)

Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity.

Acedapsone, or 1399 F, is a diacetyl compound, derived from dapsone. It was synthesized and developed in 1937 by Ernest Fourneau and his team in the pharmaceutical chemistry laboratory of Pasteur Institute, and it was marketed as Rodilone by the Rhône-Poulenc company.

It is a long-acting prodrug of dapsone. It is used for treating leprosy.

It crystallises as pale yellow needles from diethyl ether, and as leaflets from dilute ethanol. It is slightly soluble in water.