Acetogenin
Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by linear 32- or 34-carbon chains containing oxygenated functional groups including hydroxyls, ketones, epoxides, tetrahydrofurans and tetrahydropyrans. They are often terminated with a lactone or butenolide.[1] Over 400 members of this family of compounds have been isolated from 51 different species of plants.[2]
Examples include:
Use in treating cancer
Well over half all cancer patients pursue some sort of complementary and alternative medical treatments.[3] Neither purified acetogenins nor crude extracts of the pawpaw or the Brazilian pawpaw (Asimina triloba, Annonaceae) have been approved by the FDA for cancer treatment, but they have exhibited antitumor efficacy both in animal models and in a limited number of clinical studies.[4]
Both the Pawpaw extract and acetogenins appear to inhibit HIF-1 activation by blocking the hypoxic induction of nuclear HIF-1α protein.[5]
There is, in the opinion of Coothankandaswamy, a lack of rigorously controlled clinical trials, casting a shadow on the observation that the administration of pawpaw capsules rich in acetogenins decreased tumor size, reduced tumor blood flow, suppressed metastasis, and improved survival in cancer patients.
References
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External links
Media related to Lua error in package.lua at line 80: module 'strict' not found. at Wikimedia Commons
