Acetylene hydratase
| Acetylene hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.112 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
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In enzymology, an acetylene hydratase (EC 4.2.1.112) is a rare example of an enzyme containing tungsten. It catalyzes the hydration of acetylene to give acetaldehyde:[1]
- C2H2 + H2O → CH3CHO
The W centre is bound to two molybdopterin cofactors.[2] The mechanism is thought to involve attachment of acetylene to the metal followed by nucleophilic attack of water.[3]
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is acetaldehyde hydro-lyase (acetylene-forming). Other names in common use include AH, and acetaldehyde hydro-lyase. Acetylene hydratase participates in tetrachloroethene degradation.
References
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