Angiotensin-converting enzyme 2

Angiotensin I converting enzyme 2
250px PDB rendering based on 1r42.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1R42, 1R4L, 1XJP, 2AJF, 3D0G, 3D0H, 3D0I, 3KBH, 3SCI, 3SCJ, 3SCK, 3SCL
Identifiers
Symbols	ACE2 ; ACEH
External IDs	OMIM: 300335 MGI: 1917258 HomoloGene: 41448 ChEMBL: 3736 GeneCards: ACE2 Gene
EC number	3.4.17.23
Gene ontology Molecular function • virus receptor activity • glycoprotein binding • endopeptidase activity • carboxypeptidase activity • protein binding • metallopeptidase activity • peptidyl-dipeptidase activity • zinc ion binding Cellular component • extracellular region • extracellular space • cytoplasm • plasma membrane • cell surface • integral component of membrane • membrane raft • extracellular exosome Biological process • regulation of cytokine production • angiotensin maturation • angiotensin catabolic process in blood • angiotensin-mediated drinking behavior • regulation of systemic arterial blood pressure by renin-angiotensin • tryptophan transport • regulation of vasoconstriction • receptor biosynthetic process • regulation of cell proliferation • regulation of vasodilation • cellular protein metabolic process • viral entry into host cell • receptor-mediated virion attachment to host cell • regulation of inflammatory response • positive regulation of cardiac muscle contraction • positive regulation of gap junction assembly • regulation of cardiac conduction • positive regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ACE2 219962 at tn.png
File:PBB GE ACE2 222257 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59272	70008
Ensembl	ENSG00000130234	ENSMUSG00000015405
UniProt	Q9BYF1	Q8R0I0
RefSeq (mRNA)	NM_021804	NM_001130513
RefSeq (protein)	NP_068576	NP_001123985
Location (UCSC)	Chr X: 15.56 – 15.6 Mb	Chr X: 164.14 – 164.19 Mb
PubMed search	[1]	[2]

Angiotensin I converting enzyme 2 (ACE 2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9], or the conversion of angiotensin II to angiotensin 1-7. ACE 2 has direct effects on cardiac function, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.

ACE 2 is the receptor for SARS virus.

See also

• Renin-angiotensin system
• ACE inhibitors