Cytidylate kinase

cytidylate kinase
Identifiers
EC number	2.7.4.14
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a cytidylate kinase (EC 2.7.4.14) is an enzyme that catalyzes the chemical reaction

ATP + (d)CMP $\rightleftharpoons$ ADP + (d)CDP

Thus, the two substrates of this enzyme are ATP and dCMP, whereas its two products are ADP and dCDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:CMP phosphotransferase. Other names in common use include: deoxycytidylate kinase, deoxycytidylate kinase, CMP kinase, CTP:CMP phosphotransferase, dCMP kinase, deoxycytidine monophosphokinase, UMP-CMP kinase, ATP:UMP-CMP phosphotransferase, and pyrimidine nucleoside monophosphate kinase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1CKE, 1KDO, 1KDP, 1KDR, 1KDT, 1Q3T, 1QF9, 1TEV, 1UKE, 2CMK, 2FEM, 2FEO, 2H92, 2UKD, 3UKD, 4UKD, and 5UKD.

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139-149.