DGKB
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Diacylglycerol kinase, beta 90kDa | |||||||||||||
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Identifiers | |||||||||||||
Symbols | DGKB ; DAGK2; DGK; DGK-BETA | ||||||||||||
External IDs | OMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB Gene | ||||||||||||
EC number | 2.7.1.107 | ||||||||||||
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RNA expression pattern | |||||||||||||
File:PBB GE DGKB 216307 at tn.png | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 1607 | 217480 | |||||||||||
Ensembl | ENSG00000136267 | ENSMUSG00000036095 | |||||||||||
UniProt | Q9Y6T7 | Q6NS52 | |||||||||||
RefSeq (mRNA) | NM_004080 | NM_178681 | |||||||||||
RefSeq (protein) | NP_004071 | NP_848796 | |||||||||||
Location (UCSC) | Chr 7: 14.15 – 14.97 Mb |
Chr 12: 37.88 – 38.63 Mb |
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PubMed search | [1] | [2] | |||||||||||
Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[1][2]
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[2]
References
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Further reading
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