Desmoglein-1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene.[1][2]
Function
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein-1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.[2]
Interactions
Desmoglein-1 has been shown to interact with PKP3,[3] PKP2,[4] and PTPRT(PTPrho)[5]
See also
- Desmoglein
- List of target antigens in pemphigus
- List of conditions caused by problems with junctional proteins
References
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Further reading
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