E. Premkumar Reddy

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E. Premkumar Reddy is a biologist.

Studies

Lua error in package.lua at line 80: module 'strict' not found. He obtained his Ph. D. in molecular biology in 1971 from the Regional Research Laboratory and Osmania University, Hyderabad, India.

After post-doctoral training in the United States of America at the UCLA School of Medicine and the National Cancer Institute (NCI).

Professional career

Lua error in package.lua at line 80: module 'strict' not found. He joined the National Cancer Institute after his post-graduation, with which he was associated till 1984 as the chief of the molecular genetics section.

In 1984, he moved to Hoffman LaRoche Roche Institute of Molecular Biology as a full member and in 1986, he joined the Wistar Institute as their deputy director. In 1992, he was appointed as the Director of the Fels Institute for Cancer Research and Molecular Biology, which is affiliated with Temple University.

He moved to the Mount Sinai School of Medicine in 2010 where he is the Director of Experimental Cancer Therapeutics program and Professor in the Departments of Oncological Sciences and Structural and Chemical Biology. Dr. Reddy served as a member of the board of directors of NIEHS from 1990-1995. In 1993, he was awarded the Scientific Achievement award by the American Cancer Society.

Findings

Lua error in package.lua at line 80: module 'strict' not found. He made a number of seminal discoveries that provided a clear understanding of the molecular basis of cancer. He cloned and sequenced a number of viral oncogenes which included mos,[1] abl,[2][3] ras,[2][4] fgr,[5] myb,[6][7] myc[8][9] and sis[10][11] oncogenes and their cellular homologues which pinpointed the precise changes that cellular proto-oncogenes undergo to produce cancer-causing viral oncogenes. He extended this work to human cancers and was responsible for the seminal discovery that point mutations in the cellular ras genes result in their oncogenic activation.[12][13] His work also showed the mechanisms associated with the activation of Abl and Myb oncogenes, which are associated with the development of human myelogenous leukemias.[14][15] His recent work on cell cycle regulator, Cdk4 has shown that this gene is very critical for the development of ErbB2 and ras oncogene-induced tumors and inhibition of expression of Cdk4 causes ablation of breast cancers caused by ErbB2 and Ras oncogenes.[16][17] His most recent findings include the generation of A-myb, c-myb and CDK4 null mutant mice[18][19][20][21] and delineation of the apoptotic mechanisms associated with hematopoietic cell death.

His recent work centers around the role of cell cycle and apoptotic genes in cancer progression and as targets for the development of novel anticancer drugs. This work has led to the development of novel therapeutic agents that can differentially induce apoptosis in tumor cells and spare normal cells. One of the drugs developed by his team (ON01910/Estybon/Rigosertib) is currently in Phase III clinical trials and shows promise as a powerful anti-cancer agent, especially for the treatment of Myelo Dysplastic Syndrome (MDS) and pancreatic cancer.[22][23][24][25]

Publications and Journalism

Lua error in package.lua at line 80: module 'strict' not found. He co-founded the international cancer journal Oncogene in 1986, for which he served as an Editor from 1986 to 2009. In 2010, he founded a new cancer journal named 'Genes & Cancer' for which he serves as the Editor-in-Chief.

Reddy has published over 250 papers. The most notable of his findings are the molecular cloning and sequence determination of a number of viral oncogenes and their cellular homologues.

According to data published in 2000 by the Institute for Scientific Information, which compiled the list of most highly cited authors, Dr. Reddy was amongst the top 0.5% of the most highly cited authors in the world.

Related links

References

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