FKBP52

FK506 binding protein 4, 59kDa
250px PDB rendering based on 1n1a.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1N1A, 1P5Q, 1Q1C, 1QZ2, 4DRJ, 4LAV, 4LAW, 4LAX, 4LAY, 4TW8
Identifiers
Symbols	FKBP4 ; FKBP51; FKBP52; FKBP59; HBI; Hsp56; PPIase; p52
External IDs	OMIM: 600611 MGI: 95543 HomoloGene: 36085 ChEMBL: 4050 GeneCards: FKBP4 Gene
EC number	5.2.1.8
Gene ontology Molecular function • peptidyl-prolyl cis-trans isomerase activity • protein binding • ATP binding • GTP binding • FK506 binding • protein binding, bridging • heat shock protein binding • copper-dependent protein binding • glucocorticoid receptor binding • poly(A) RNA binding • tau protein binding • phosphoprotein binding Cellular component • nucleoplasm • cytoplasm • mitochondrion • endoplasmic reticulum membrane • cytosol • microtubule • neuronal cell body • axonal growth cone • perinuclear region of cytoplasm • extracellular exosome Biological process • protein peptidyl-prolyl isomerization • protein folding • steroid hormone receptor complex assembly • copper ion transport • embryo implantation • negative regulation of neuron projection development • androgen receptor signaling pathway • prostate gland development • negative regulation of microtubule polymerization or depolymerization • negative regulation of microtubule polymerization • protein complex localization • cellular response to heat • male sex differentiation • chaperone-mediated protein folding • regulation of cellular response to heat Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FKBP4 200895 s at tn.png
File:PBB GE FKBP4 200894 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2288	14228
Ensembl	ENSG00000004478	ENSMUSG00000030357
UniProt	Q02790	P30416
RefSeq (mRNA)	NM_002014	NM_010219
RefSeq (protein)	NP_002005	NP_034349
Location (UCSC)	Chr 12: 2.79 – 2.81 Mb	Chr 6: 128.43 – 128.44 Mb
PubMed search	[1]	[2]

FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.

This protein contains TPR repeats and has a PPlase domain.

Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.

Interactions

FKBP52 has been shown to interact with GLMN.

See also

• Glucocorticoid receptor
• Immunophilins
• FKBP5

External links

• FKBP52 at the US National Library of Medicine Medical Subject Headings (MeSH)