ITGA11

Integrin, alpha 11
Identifiers
Symbols	ITGA11 ; HsT18964
External IDs	OMIM: 604789 MGI: 2442114 HomoloGene: 8151 ChEMBL: 5883 GeneCards: ITGA11 Gene
Gene ontology Molecular function • collagen binding • collagen receptor activity • metal ion binding • collagen binding involved in cell-matrix adhesion Cellular component • plasma membrane • focal adhesion • integrin complex • membrane • integrin alpha11-beta1 complex Biological process • osteoblast differentiation • substrate-dependent cell migration • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • muscle organ development • extracellular matrix organization • cell adhesion mediated by integrin • collagen-activated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ITGA11 gnf1h00121 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22801	319480
Ensembl	ENSG00000137809	ENSMUSG00000032243
UniProt	Q9UKX5	Q7TQC3
RefSeq (mRNA)	NM_001004439	NM_176922
RefSeq (protein)	NP_001004439	NP_795896
Location (UCSC)	Chr 15: 68.3 – 68.43 Mb	Chr 9: 62.68 – 62.78 Mb
PubMed search	[1]	[2]

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.

External links

• ITGA11 Info with links in the Cell Migration Gateway