Iohexol

Iohexol

Systematic (IUPAC) name
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: B (No risk in non-human studies)
Legal status	℞ (Prescription only)
Routes of administration	Intrathecal, intravascular, oral, intracavital, rectal
Pharmacokinetic data
Protein binding	Low
Metabolism	Nil
Biological half-life	Variable
Excretion	Renal, unchanged
Identifiers
CAS Number	66108-95-0 Y
ATC code	V08AB02 (WHO)
PubChem	CID: 3730
DrugBank	DB01362 Y
ChemSpider	3599 Y
UNII	4419T9MX03 Y
KEGG	D01817 Y
ChEBI	CHEBI:31709 Y
ChEMBL	CHEMBL1200455 N
Synonyms	5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
Chemical data
Formula	C19H26I3N3O9
Molecular mass	821.138 g/mol
SMILES O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C
InChI InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) Y Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Iohexol is a contrast agent, sold under the trade names Omnipaque and Exypaque; this compound is also sold as a density gradient medium under the names Accudenz, Histodenz and Nycodenz. It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood. Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.

External links

• Omnipaque (Iohexol) injection, solution