Multisite-specific tRNA:(cytosine-C5)-methyltransferase
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| Multisite-specific tRNA:(cytosine-C5)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.202 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Multisite-specific tRNA:(cytosine-C5)-methyltransferase (EC 2.1.1.202, multisite-specific tRNA:m5C-methyltransferase, TRM4 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine-C5)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor - (2) S-adenosyl-L-methionine + cytosine40 in tRNA precursor S-adenosyl-L-homocysteine + 5-methylcytosine40 in tRNA precursor
- (3) S-adenosyl-L-methionine + cytosine48 in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine48 in tRNA
- (4) S-adenosyl-L-methionine + cytosine49 in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine49 in tRNA
The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA.
References
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<references />, or <references group="..." />External links
- Multisite-specific tRNA:(cytosine-C5)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
