Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.[1][2]
Function
Nitric oxide (NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter and may be involved in long term potentiation. It is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. Neuronal NOS and macrophage NOS are distinct isoforms.[3] Both the neuronal and the macrophage forms are unusual among oxidative enzymes in requiring several electron donors: FAD, flavin mononucleotide (FMN), NADPH, and tetrahydrobiopterin.[4]
Clinical significance
It has been implicated in asthma,[5][6] schizophrenia[7][8] and restless leg syndrome.[9] It has also been investigated with respect to bipolar disorder [10] and air pollution exposure.[11]
Interactions
NOS1 has been shown to interact with DLG4[12][13] and NOS1AP.[12]
See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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1b8q: SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE
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1f20: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION.
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1k2r: Structure of rat brain nNOS heme domain complexed with NG-nitro-L-arginine
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1k2s: Structure of rat brain nNOS heme domain complexed with NG-allyl-L-arginine
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1k2t: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-phenyl-isothiourea
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1k2u: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-[4-(trifluoromethyl)phenyl] isothiourea
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1lzx: Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound
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1lzz: Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound
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1m00: Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound
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1mmv: Rat neuronal NOS heme domain with NG-propyl-L-arginine bound
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1mmw: Rat neuronal NOS heme domain with vinyl-L-NIO bound
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1om4: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND
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1om5: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH 3-BROMO-7-NITROINDAZOLE BOUND
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1p6h: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
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1p6i: Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
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1p6j: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound
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1p6k: Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
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1qau: UNEXPECTED MODES OF PDZ DOMAIN SCAFFOLDING REVEALED BY STRUCTURE OF NNOS-SYNTROPHIN COMPLEX
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1qav: Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin Complex
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1qw6: Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.
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1qwc: Rat neuronal nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.
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1rs6: Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound
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1rs7: Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound
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1tll: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
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1vag: Neuronal nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477
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1zvi: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain
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1zvl: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain complexed with natural substrate L-Arg.
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1zzq: Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound
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1zzr: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound
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1zzu: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Bound
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2g6h: Structure of rat nNOS heme domain (BH4 bound) in the reduced form
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2g6i: Structure of rat nNOS heme domain (BH2-bound) in the reduced form
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2g6j: Structure of rat nNOS (L337N) heme domain (4-aminobiopterin bound) complexed with NO
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2g6k: Structure of rat nNOS heme domain (BH4 bound) complexed with NO
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2g6l: Structure of rat nNOS heme domain (BH2 bound) complexed with NO
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2g6m: Structure of rat nNOS heme domain (BH4 bound) complexed with CO
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2g6n: Strcture of rat nNOS heme domain (BH2 bound) complexed with CO
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2hx3: Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine
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2hx4: Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide
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