ORM1

Orosomucoid 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3KQ0
Identifiers
Symbols	ORM1 ; AGP-A; AGP1; HEL-S-153w; ORM
External IDs	OMIM: 138600 MGI: 97445 HomoloGene: 128040 ChEMBL: 4285 GeneCards: ORM1 Gene
Gene ontology Molecular function • protein binding Cellular component • extracellular region • extracellular space • extracellular exosome • blood microparticle Biological process • regulation of immune system process • transport • acute-phase response • inflammatory response • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ORM1 205041 s at tn.png
File:PBB GE ORM1 205040 at tn.png
File:PBB GE ORM1 214465 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5004	18405
Ensembl	ENSG00000229314	ENSMUSG00000039196
UniProt	P02763	Q60590
RefSeq (mRNA)	NM_000607	NM_008768.1
RefSeq (protein)	NP_000598	NP_032794.1
Location (UCSC)	Chr 9: 114.32 – 114.33 Mb	Chr 4: 63.01 – 63.01 Mb
PubMed search	[1]	[2]

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.

See also

• Orosomucoid