Prorenone
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File:Prorenone.svg | |
Systematic (IUPAC) name | |
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(1aS,5aR,5bS,7aS,8R,10aS,10bR,10cS)-5a,7a-Dimethyl-1,1a,3',4,4',5,5a,5b,6,7,7a,9,10,10a,10b,10c-hexadecahydro-3H,5'H-spiro[cyclopenta[a]cyclopropa[l]phenanthrene-8,2'-furan]-3,5'-dione
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Identifiers | |
CAS Number | 49848-04-6 |
PubChem | CID: 170819 |
IUPHAR/BPS | 2876 |
DrugBank | DB00700 |
ChemSpider | 149344 |
Synonyms | 3-(17β-Hydroxy-6β,7β-methylene-3-oxo-4-androsten-17α-yl)propionic acid γ-lactone |
Chemical data | |
Formula | C23H30O3 |
Molecular mass | 354.48 g/mol |
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Prorenone (code names SC-23133, AC1L56BB) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed.
Chemical synthesis
Prorenone can be synthesized via a Johnson–Corey–Chaykovsky reaction by reaction of canrenone with trimethylsulfonium iodide and sodium hydride.[1]
See also
References
- ↑ Chinn, L.; 1974, U.S. Patent 3,845,041
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