RGS18
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]
Function
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]
Interactions
RGS18 has been shown to interact with GNAI3.[3][4]
References
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