RNASE1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]
Function
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]
References
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