Renal chloride reabsorption

Renal reabsorption of chloride (Cl⁻) is a part of renal physiology, in order not to lose too much chloride in the urine.

Overview table

Characteristics of Cl⁻ reabsorption

Characteristic	proximal tubule			loop of Henle			Distal convoluted tubule	Collecting duct system
	S1	S2	S3	descending limb	thin ascending limb	thick ascending limb		connecting tubule	initial collecting tubule	cortical collecting ducts	medullary collecting ducts
reabsorption (%)
reabsorption (mmoles/day)
Concentration (mM)	115		135
electrical driving force (mV)	−3		+3			+15	−5 to +5			−40
chemical driving force (mV)
electrochemical driving force (mV)	(positive)
apical transport proteins	(passively)		Cl-formate exchanger Cl-oxalate exchanger Cl−/HCO3− exchanger Cl−-OH− exchanger			Na-K-2Cl cotransporter	Na-Cl cotransporter			principal cells: paracellularily
basolateral transport proteins			chloride channels Cl-K cotransporter			chloride channels	chloride channels			chloride channels β intercalated cells: Cl−HCO3− exchanger
Other reabsorption features