SB-408124

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SB-408124
SB-408,124.svg
Systematic (IUPAC) name
1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea
Identifiers
CAS Number 288150-92-5 YesY
PubChem CID: 4331799
IUPHAR/BPS 1704
ChemSpider 3536200 N
Chemical data
Formula C19H18F2N4O
Molecular mass 356.368 g/mol
  • c3cc(N(C)C)ccc3NC(=O)Nc1cc(C)nc2c1cc(F)cc2F
  • InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) N
  • Key:JTARFZSNUAGHRB-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

SB-408124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX1, with around 70x selectivity for OX1 over OX2 receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334867. It is used in scientific research into the function of orexinergic neurons in the body.[1][2]

References

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