SKIP

This article is about a human gene. For the kanji indexing system, see Kodansha Kanji Learner's Dictionary. For the non-profit organizations, see SKIP of New York.

Inositol polyphosphate-5-phosphatase K
Identifiers
Symbols	INPP5K ; PPS; SKIP
External IDs	OMIM: 607875 MGI: 1194899 HomoloGene: 75059 GeneCards: INPP5K Gene
EC number	3.1.3.56
Gene ontology Molecular function • inositol-polyphosphate 5-phosphatase activity • vasopressin receptor activity • protein binding • inositol bisphosphate phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity • phosphatidylinositol trisphosphate phosphatase activity • phosphatidylinositol phosphate 5-phosphatase activity • lipid phosphatase activity • inositol trisphosphate phosphatase activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component • ruffle • nucleus • cytoplasm • endoplasmic reticulum • trans-Golgi network • cytosol • plasma membrane • membrane • ruffle membrane • neuron projection • perinuclear region of cytoplasm Biological process • in utero embryonic development • negative regulation of protein phosphorylation • regulation of glycogen biosynthetic process • negative regulation of protein kinase activity • protein dephosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • G-protein coupled receptor signaling pathway • negative regulation of peptidyl-threonine phosphorylation • negative regulation of glucose transport • dephosphorylation • actin cytoskeleton organization • cellular response to insulin stimulus • cellular response to hormone stimulus • negative regulation of peptidyl-serine phosphorylation • negative regulation of dephosphorylation • positive regulation of urine volume • glucose homeostasis • negative regulation of MAP kinase activity • negative regulation by host of viral transcription • small molecule metabolic process • negative regulation of glycogen biosynthetic process • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of insulin receptor signaling pathway • inositol phosphate dephosphorylation • phosphatidylinositol dephosphorylation • negative regulation of stress fiber assembly • negative regulation of protein kinase B signaling • negative regulation of calcium ion transport • cellular response to cAMP • cellular response to tumor necrosis factor • cellular response to epidermal growth factor stimulus • protein targeting to plasma membrane • negative regulation of protein targeting to membrane • ruffle assembly • negative regulation of glycogen (starch) synthase activity • positive regulation of renal water transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SKIP 202781 s at tn.png
File:PBB GE SKIP 202782 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51763	19062
Ensembl	ENSG00000132376	ENSMUSG00000006127
UniProt	Q9BT40	Q8C5L6
RefSeq (mRNA)	NM_001135642	NM_008916
RefSeq (protein)	NP_001129114	NP_032942
Location (UCSC)	Chr 17: 1.49 – 1.52 Mb	Chr 11: 75.63 – 75.65 Mb
PubMed search	[1]	[2]

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.

Function

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.