SOS box
SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription of SOS-induced proteins. This occurs in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator. SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism.[1] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[2]
Examples
| Phylogenetic Clade | Sequence | Reference |
|---|---|---|
| Alpha Proteobacteria | GAAC(N)7GAAC GTTC(N)7GTTC |
[3][4] |
| Betaproteobacteria Gammaproteobacteria |
CTGT(N)8ACAG | [5] |
| Deltaproteobacteria | CTRHAMRYBYGTTCAGS | [6] |
| Gram-positive Bacteria | CGAACRNRYGTTYC | [7][8] |
| Cyanobacteria | RGTAC(N)3DGTWCB | [9] |
See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters
See also
References
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