STXBP5

Syntaxin binding protein 5 (tomosyn)
250px PDB rendering based on 1urq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1urq
Identifiers
Symbols	STXBP5 ; LGL3; LLGL3; Nbla04300
External IDs	OMIM: 604586 MGI: 1926058 HomoloGene: 16402 GeneCards: STXBP5 Gene
Gene ontology Molecular function • syntaxin-1 binding Cellular component • cytoplasm • acetylcholine-gated channel complex • synaptic vesicle • cell junction • cytoplasmic vesicle membrane Biological process • exocytosis • regulation of gene expression • protein transport • regulation of exocytosis • regulation of blood coagulation • positive regulation of exocytosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	134957	78808
Ensembl	ENSG00000164506	ENSMUSG00000019790
UniProt	Q5T5C0	Q8K400
RefSeq (mRNA)	NM_001127715	NM_001081344
RefSeq (protein)	NP_001121187	NP_001074813
Location (UCSC)	Chr 6: 147.2 – 147.39 Mb	Chr 10: 9.76 – 9.9 Mb
PubMed search	[1]	[2]

Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene.

Function

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.

Interactions

STXBP5 has been shown to interact with STX4 and STX1A.