Sepiapterin reductase

Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
PDB rendering based on 1z6z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Z6Z, 4HWK, 4J7U, 4J7X
Identifiers
Symbols	SPR ; SDR38C1
External IDs	OMIM: 182125 MGI: 103078 HomoloGene: 37735 GeneCards: SPR Gene
EC number	1.1.1.153
Gene ontology Molecular function • aldo-keto reductase (NADP) activity • sepiapterin reductase activity • NADP binding Cellular component • nucleoplasm • cytoplasm • mitochondrion • cytosol • extracellular exosome Biological process • L-phenylalanine metabolic process • tetrahydrobiopterin biosynthetic process • nitric oxide biosynthetic process • death • pteridine metabolic process • regulation of multicellular organism growth • norepinephrine metabolic process • dopamine metabolic process • serotonin metabolic process • small molecule metabolic process • nitric oxide metabolic process • cell morphogenesis involved in neuron differentiation • voluntary musculoskeletal movement • regulation of nitric-oxide synthase activity • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6697	20751
Ensembl	ENSG00000116096	ENSMUSG00000033735
UniProt	P35270	Q91XH5
RefSeq (mRNA)	NM_003124	NM_011467
RefSeq (protein)	NP_003115	NP_035597
Location (UCSC)	Chr 2: 72.89 – 72.89 Mb	Chr 6: 85.13 – 85.14 Mb
PubMed search	[1]	[2]

Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.

Function

Sepiapterin reductase (7,8-dihydrobiopterin:NADP⁺ oxidoreductase; EC 1.1.1.153) catalyzes the NADPH-dependent reduction of various carbonyl substances, including derivatives of pteridines, and belongs to a group of enzymes called aldo-keto reductases. SPR plays an important role in the biosynthesis of tetrahydrobiopterin.

Reaction

sepiapterin reductase
Identifiers
EC number	1.1.1.153
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Sepiapterin reductase (SPR) catalyzes the chemical reaction

L-erythro-7,8-dihydrobiopterin + NADP+ $\rightleftharpoons$ sepiapterin + NADPH + H+

Thus, the two substrates of this enzyme are L-erythro-7,8-dihydrobiopterin and NADP⁺, whereas its three products are sepiapterin, NADPH, and a single hydrogen ion (H⁺).

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 7,8-dihydrobiopterin:NADP⁺ oxidoreductase. This enzyme participates in folate biosynthesis.