Sodium citrate/sodium lauryl sulfoacetate/glycerol

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Combination of
Sodium citrate Laxative
Sodium lauryl sulfoacetate Laxative
Glycerol Laxative
Clinical data
Trade names Microlax, Micolette Micro enema
AHFS/Drugs.com International Drug Names
Identifiers
ATC code A06AG11 (WHO)

Sodium citrate/sodium lauryl sulfoacetate/glycerol sold under the brandname Microlax and Micolette Micro enema among others, is a small tube of liquid gel that is used to treat constipation.[1] It is a fast-acting enema that works as a laxative. It is classified as a ATC code A06 drug in the Anatomical Therapeutic Chemical Classification System.

The main active ingredients are sodium lauryl sulfoacetate (0.90% w/v), sodium citrate (9.0% w/v) and glycerol.[2]

Medical uses

The main use is for treatment of constipation.

In surgery it is used for pre-operative evacuation of the bowel.[3]

In clinical investigation Microlax is used before x-ray examinations or physical examinations of the colon.

It has no age limits in regards to children and can be used safely.[4] If used in children under 3 years it is recommended that the nozzle is only inserted half way.[5]

It is safe to use during pregnancy.[6]

It is suggested as a laxative during postnatal period[7] and it is compatible with breastfeeding[8]

Contraindications

Microlax (like any other saline laxative) should not be used in cases if intesinal inflammation.[9]

Side effects

Possible side effects of:

  • slight rectal burning sensation,[10][11]
  • individual cases of allergy or abnormal reaction,[10]
  • general skin reaction with or without low blood pressure or breathing difficulties.[10]

Mechanism of action

Sodium citrate saline is one of the most effective osmotic laxatives (secondary in action only to magnesium citrate).[9] Laxative action is the result of osmotic imbalance that extracts bound water from stool and pulls it back into the large bowel. Increased water content softens the stool and stimulates the bowel to contract (move its contents to the rectum).

Sodium lauryl sulfoacetate improves the wetting and penetrating abilities of the solution, sorbitol enhances the water-releasing effect of sodium citrate and glycerol helps to lubricate the stool.

The combined action of "Microlax" sub-components helps to soften hard stools and relieve constipation without straining in a very short period of time (typically from 2[12] to 15 min,[13] in rare occasions up to 30 min[6]).

"Microlax" ingedients are not absorbed, distributed or metabolised by the human body, all of the composition is being excreted in faeces.[13]

History

1960 - Microlax micro-enema was invented in Sweden by Paul Gunnar Embring from Uppsala and Per Ove Mattsson from Stockholm for Pharmacia company.[14] The original purpose of the invention was to offer solution that allowed to clear the colon and rectum for X-ray investigation "without any risk of the fluid balance of the body being disturbed".[14]

First use of "Microlax" in commerce was registered in June 16, 1960.[15]

1962 - Microlax registered as the US trademark in February 20, 1962.[15]

1963 - In May 1963 first medical article on Microlax published in Danish medical journal Ugeskrift for Læger (Weekly Journal for Physicians).[16]

1964 - Microenema containing sodium citrate, sodium laurylsulphoacetate and sorbitol has been tested in preparation of the bowel for sigmoidoscopy. Results were published in the American Journal of Proctology.[17]

1965 - Comparative study of Microlax and enema published in Ugeskrift for Læger.[18]

1967 - "The use of a micro-enema as preparation for sigmoidoscopy" article, published in "The Medical Journal of Australia" proved the results of 1964 US study and confirmed the efficiency of using Microlax as part of preparation for sigmoidoscopy.[19]

1996 - The study published in Journal of the Royal Society of Medicine suggested to mail "Microlax" micro-enemas to patients who are scheduled for sigmoidoscopy.[20]

References

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