Transforming growth factor, beta 3

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.[1][2]

It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.[3]

TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.[4][5] This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue,[6] and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.[1]

Interactions

Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.[7][8][9][10]

Clinical research

After successful phase I/II trials,[11] human recombinant TGF-β3 (Avotermin, planned trade name Juvista) failed in Phase III trials.[12]

References

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External links

Further reading

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  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
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  12. ↑ Renovo shares plummet 75% as scar revision product Juvista fails to meet study endpoints, 14 February 2011
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