TIGRFAMs
TIGRFAMs is a database of protein families designed to support manual and automated genome annotation.[1][2][3] Each entry includes a multiple sequence alignment and hidden Markov model (HMM) built from the alignment. Sequences that score above the defined cutoffs of a given TIGRFAMs HMM are assigned to that protein family and may be assigned the corresponding annotations.
Like Pfam, TIGRFAMs uses the HMMER package written by Sean Eddy.[4] TIGRFAMs is produced at the J. Craig Venter Institute. It is one of 11 member databases in InterPro. The current version of TIGRFAMs, release 13.0, has over 4200 models.
References
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<references />, or <references group="..." />External links
- http://www.jcvi.org/cgi-bin/tigrfams/index.cgi - TIGRFAMs home page
- http://hmmer.janelia.org/search/hmmscan - high speed search of protein sequences against Pfam or TIGRFAMs libraries at Janelia Farm Research Campus
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