Template:PBB/7166

Tryptophan hydroxylase 1
PDB rendering based on 1mlw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1IN9, 1MLW, 3HF6, 3HF8, 3HFB
Identifiers
Symbols	TPH1 ; TPRH; TRPH
External IDs	OMIM: 191060 MGI: 98796 HomoloGene: 121565 ChEMBL: 5689 GeneCards: TPH1 Gene
EC number	1.14.16.4
Gene ontology Molecular function • tryptophan 5-monooxygenase activity • iron ion binding • amino acid binding Cellular component • cytosol • neuron projection Biological process • circadian rhythm • aromatic amino acid family metabolic process • negative regulation of ossification • cellular nitrogen compound metabolic process • response to immobilization stress • serotonin biosynthetic process • small molecule metabolic process • positive regulation of fat cell differentiation • indolalkylamine biosynthetic process • bone remodeling • oxidation-reduction process • mammary gland alveolus development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7166	21990
Ensembl	ENSG00000129167	ENSMUSG00000040046
UniProt	P17752	P17532
RefSeq (mRNA)	NM_004179	NM_001136084
RefSeq (protein)	NP_004170	NP_001129556
Location (UCSC)	Chr 11: 18.02 – 18.04 Mb	Chr 7: 46.65 – 46.67 Mb
PubMed search	[1]	[2]