Template:PBB/860

Runt-related transcription factor 2
PDB rendering based on 1cmo.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1cmo, 1co1, 1e50, 1h9d, 1hjb, 1hjc, 1io4, 1ljm
Identifiers
Symbols	RUNX2 ; AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA
External IDs	OMIM: 600211 MGI: 99829 HomoloGene: 68389 GeneCards: RUNX2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • ATP binding • protein domain specific binding • histone deacetylase binding • bHLH transcription factor binding • repressing transcription factor binding Cellular component • nuclear chromatin • nucleoplasm • transcription factor complex • cytoplasm Biological process • ossification • osteoblast differentiation • endochondral ossification • osteoblast fate commitment • chondrocyte differentiation • chondrocyte development • osteoblast development • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • positive regulation of cell proliferation • gene expression • hemopoiesis • neuron differentiation • T cell differentiation • BMP signaling pathway • positive regulation of chondrocyte differentiation • embryonic forelimb morphogenesis • regulation of fibroblast growth factor receptor signaling pathway • odontogenesis of dentin-containing tooth • regulation of odontogenesis of dentin-containing tooth • cellular response to fibroblast growth factor stimulus • regulation of cell differentiation • positive regulation of osteoblast differentiation • negative regulation of smoothened signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • cell maturation • embryonic cranial skeleton morphogenesis • stem cell differentiation • cellular response to BMP stimulus • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	860	12393
Ensembl	ENSG00000124813	ENSMUSG00000039153
UniProt	Q13950	Q08775
RefSeq (mRNA)	NM_001015051	NM_001145920
RefSeq (protein)	NP_001015051	NP_001139392
Location (UCSC)	Chr 6: 45.33 – 45.66 Mb	Chr 17: 44.5 – 44.81 Mb
PubMed search	[1]	[2]