UDP-N-acetylglucosamine diphosphorylase

UDP-N-acetylglucosamine diphosphorylase
Identifiers
EC number	2.7.7.23
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate $\rightleftharpoons$ diphosphate + UDP-N-acetyl-D-glucosamine

Thus, the two substrates of this enzyme are UTP and[N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FWY, 1FXJ, 1G95, 1G97, 1HM0, 1HM8, 1HM9, 1HV9, 1JVD, 1JVG, 1VM8, 2NPO, 2OI5, 2OI6, 2OI7, 2YQC, 2YQH, 2YQJ, and 2YQS.