V600E
From Infogalactic: the planetary knowledge core
V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamine (E) at codon 600.[1][2] It is a driver mutation in a proportion of certain diagnoses, including melanoma,[3][4] hairy cell leukemia,[5][6] papillary thyroid carcinoma,[7][8] colorectal cancer,[9] non-small-cell lung cancer,[10][11] Langerhans cell histiocytosis,[12] and ameloblastoma.[13]
Clinical
Vemurafenib and dabrafenib are approved by the FDA for treatment of melanomas that express V600E.
References
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