XCR1

Chemokine (C motif) receptor 1
Identifiers
Symbols	XCR1 ; CCXCR1; GPR5
External IDs	OMIM: 600552 MGI: 1346338 HomoloGene: 21095 IUPHAR: 75 ChEMBL: 4339 GeneCards: XCR1 Gene
Gene ontology Molecular function • chemokine receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cytosolic calcium ion concentration • release of sequestered calcium ion into cytosol • chemokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2829	23832
Ensembl	ENSG00000173578	ENSMUSG00000060509
UniProt	P46094	Q9R0M1
RefSeq (mRNA)	NM_001024644	NM_011798
RefSeq (protein)	NP_001019815	NP_035928
Location (UCSC)	Chr 3: 46.02 – 46.03 Mb	Chr 9: 123.85 – 123.86 Mb
PubMed search	[1]	[2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

External links

• XCR1 receptor, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.