3-hydroxy-2-methylpyridinecarboxylate dioxygenase

3-hydroxy-2-methylpyridinecarboxylate dioxygenase
Identifiers
EC number	1.14.12.4
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-hydroxy-2-methylpyridinecarboxylate dioxygenase (EC 1.14.12.4) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H⁺ + O₂ $\rightleftharpoons$ 2-(acetamidomethylene)succinate + NAD(P)+

The 5 substrates of this enzyme are 3-hydroxy-2-methylpyridine-5-carboxylate, NADH, NADPH, H⁺, and O₂, whereas its 3 products are 2-(acetamidomethylene)succinate, NAD⁺, and NADP⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor. The systematic name of this enzyme class is 3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing). Other names in common use include methylhydroxypyridinecarboxylate oxidase, 2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase, methylhydroxypyridine carboxylate dioxygenase, and 3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect]. This enzyme participates in vitamin B₆ metabolism. It employs one cofactor, FAD.