ANGPT2

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.^[1]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[2]

1 Interactions
2 See also
3 References
4 Further reading

Interactions

ANGPT2 has been shown to interact with TEK tyrosine kinase.^[3]^[4]^[5]

References

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PDB gallery

1z3s: Angiopoietin-2 Receptor Binding Domain

1z3s: Angiopoietin-2 Receptor Binding Domain

1z3u: Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition

1z3u: Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition

2gy7: Angiopoietin-2/Tie2 Complex Crystal Structure

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Antiangiogenics
Endogenous Regulation	Angiopoietin 2 angiostatin canstatin calreticulin endostatin IFN-α IFN-β IFN-γ CXCL10 IL-4 IL-12 IL-18 maspin Meth-1 Meth-2 osteopontin platelet factor-4 prolactin proliferin-related protein prothrombin (kringle domain-2) antithrombin III fragment SPARC Thrombospondin 1 TIMP vasostatin VEGI soluble VEGFR-1 NRP-1 CDAI
Exogenous Regulation	2-Methoxyestradiol α_Vβ₃ inhibitors angiostatic steroids heparin angiostatin bevacizumab carboxyamidotriazole Cartilage-Derived Angiogenesis Inhibitory Factor CM101 endostatin IFN-α IL-12 itraconazole linomide matrix metalloproteinase inhibitors platelet factor-4 prolactin SU5416 suramin tasquinimod tecogalan tetrathiomolybdate thalidomide thrombospondin thrombospondin TNP-470 VEGFR antagonists
See also	Angiogenesis Angiogenesis inhibitors

v t e Proteins: angiogenesis
angiogenic	Angiogenin Angiopoietin (ANGPT1, ANGPT2) Perlecan Vascular endothelial growth factor (A, B, C, D, PGF)
anti-angiogenic	Angiostatin Endostatin
See also Proteases in angiogenesis

Growth factor receptor modulators

Angiopoietin

Agonists: Angiopoietin 1
Angiopoietin 4

Antagonists: Angiopoietin 2
Angiopoietin 3

Antibodies: Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

Agonists: Axokine
CNTF

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists: Amphiregulin Betacellulin EGF (nepidermin, urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Transforming growth factor alpha (TGFα) Antibodies: Cetuximab Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab Kinase inhibitors: Afatinib AG-490 Brigatinib Canertinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154
ErbB2/HER2	Agonists: Unknown/none Antibodies: Ertumaxomab Pertuzumab Trastuzumab Trastuzumab emtansine Kinase inhibitors: Afatinib AG-490 Lapatinib Neratinib
ErbB3/HER3	Agonists: Neuregulins (heregulins) (1, 2, 6 (neuroglycan C)) Antibodies: Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists: Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1, 2, 3, 4, 5 (tomoregulin, TMEFF))

FGF

FGFR1	FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20)
FGFR2	FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF; palifermin), 8, 9, 10 (KGF2), 17, 18, 22)
FGFR3	FGF (1, 2 (bFGF), 4, 8, 9, 18, 23)
FGFR4	FGF (1, 2 (bFGF), 4, 6, 8, 9, 19)
Unsorted	FGF15/19

HGF (c-Met)

Agonists: Hepatocyte growth factor

Potentiators: Dihexa (PNB-0408)

IGF
(somatomedin)

IGF-1	Agonists: des(1-3)IGF-1 Insulin-like growth factor-1 (somatomedin C) (mecasermin, mecasermin rinfabate) IGF-1 LR3 Insulin-like growth factor-2 (somatomedin A) Insulin Antagonists: BMS-754807 Antibodies: AVE1642 Cixutumumab Dalotuzumab Figitumumab Ganitumab Robatumumab R1507 Teprotumumab Kinase inhibitors: Linsitinib NVP-ADW742 NVP-AEW541 OSl-906
IGF-2	Agonists: Insulin-like growth factor-2 (somatomedin A) Antibodies: Dusigitumab
Others	Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7) Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) Trofinetide

LNGF

Agonists: BDNF
NGF
NT-3
NT-4

Antagonists: SAR127963

Antibodies: Against NGF: Fasinumab
Fulranumab
Tanezumab

PDGF

Agonists: Platelet-derived growth factor (A, B, C, D)

RET (GFL)

GFRα1	Agonists: Glial cell line-derived neurotrophic factor (GDNF) Kinase inhibitors: Vandetanib
GFRα2	Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib
GFRα3	Agonists: Artemin (ARTN) Kinase inhibitors: Vandetanib
GFRα4	Agonists: Persephin (PSPN) Kinase inhibitors: Vandetanib

SCF (c-Kit)

Agonists: Ancestim
Stem cell factor

TGFβ

See here instead.

Trk

TrkA	Agonists: Amitriptyline Gambogic amide NGF Tavilermide Antagonists: FX007 Kinase inhibitors: Entrectinib K252a Lestaurtinib LOXO-101 Antibodies: Against NGF: Fasinumab Fulranumab Tanezumab
TrkB	Agonists: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF Deoxygedunin Diosmetin HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 TDP6 Antagonists: ANA-12 Cyclotraxin B Gossypetin (3,5,7,8,3',4'-HHF) Kinase inhibitors: Entrectinib K252a Lestaurtinib LOXO-101
TrkC	Agonists: NT-3 Kinase inhibitors: Entrectinib K252a Lestaurtinib LOXO-101