des(1-3)IGF-1

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Des(1-3)IGF-1
Clinical data
Routes of
administration		 Intravenous administration
Identifiers
CAS Number 112603-35-7
ATC code None
Chemical data
Formula C319H501N91O96S7
Molecular mass 7371.4 g/mol

des(1-3)IGF-1 is a naturally-occurring, endogenous protein, as well as drug, and truncated analogue of insulin-like growth factor 1 (IGF-1).[1][2][3][4] des(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1).[5] As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1.[1][2][3][5]

The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.[5]

See also

References

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