CCL21

Chemokine (C-C motif) ligand 21
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L4N
Identifiers
Symbols	CCL21 ; 6Ckine; CKb9; ECL; SCYA21; SLC; TCA4
External IDs	OMIM: 602737 HomoloGene: 2247 GeneCards: CCL21 Gene
Gene ontology Molecular function • chemokine activity • CCR7 chemokine receptor binding • chemokine receptor binding • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space • intracellular Biological process • establishment of T cell polarity • immunological synapse formation • positive regulation of cell-matrix adhesion • dendritic cell chemotaxis • monocyte chemotaxis • positive regulation of dendritic cell antigen processing and presentation • inflammatory response • immune response • G-protein coupled receptor signaling pathway • cell-cell signaling • positive regulation of glycoprotein biosynthetic process • positive regulation of actin filament polymerization • positive regulation of pseudopodium assembly • T cell costimulation • ruffle organization • positive regulation of cell adhesion mediated by integrin • response to prostaglandin E • mesangial cell-matrix adhesion • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of protein kinase activity • positive regulation of JNK cascade • lymphocyte chemotaxis • positive regulation of receptor-mediated endocytosis • cell maturation • positive regulation of chemotaxis • release of sequestered calcium ion into cytosol • positive regulation of filopodium assembly • positive regulation of protein kinase B signaling • cell chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of neutrophil chemotaxis • activation of GTPase activity • dendritic cell dendrite assembly • negative regulation of leukocyte tethering or rolling • negative regulation of leukocyte apoptotic process • positive regulation of cell motility • positive regulation of T cell migration • positive regulation of myeloid dendritic cell chemotaxis • negative regulation of dendritic cell dendrite assembly Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CCL21 204606 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6366	18829
Ensembl	ENSG00000137077	ENSMUSG00000094686
UniProt	O00585	P84444
RefSeq (mRNA)	NM_002989	NM_011124
RefSeq (protein)	NP_002980	NP_035254
Location (UCSC)	Chr 9: 34.71 – 34.71 Mb	Chr 4: 42.77 – 42.77 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.