CXCL13

Chemokine (C-X-C motif) ligand 13
Identifiers
Symbols	CXCL13 ; ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13
External IDs	OMIM: 605149 MGI: 1888499 HomoloGene: 48431 GeneCards: CXCL13 Gene
Gene ontology Molecular function • chemokine activity • heparin binding • fibroblast growth factor binding • CXCR5 chemokine receptor binding • CCR10 chemokine receptor binding • protein heterodimerization activity • receptor agonist activity • CXCR3 chemokine receptor binding Cellular component • extracellular region • extracellular space • cytosol Biological process • germinal center formation • lymphocyte chemotaxis across high endothelial venule • chronic inflammatory response • regulation of humoral immune response • inflammatory response • immune response • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • positive regulation of T cell chemotaxis • response to lipopolysaccharide • positive regulation of integrin activation • positive regulation of cell-cell adhesion mediated by integrin • B cell chemotaxis • endothelial cell chemotaxis to fibroblast growth factor • B cell chemotaxis across high endothelial venule • regulation of cell proliferation • defense response to bacterium • regulation of angiogenesis • lymph node development • chemokine-mediated signaling pathway • activation of GTPase activity • negative regulation of endothelial cell chemotaxis to fibroblast growth factor Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10563	55985
Ensembl	ENSG00000156234	ENSMUSG00000023078
UniProt	O43927	O55038
RefSeq (mRNA)	NM_006419	NM_018866
RefSeq (protein)	NP_006410	NP_061354
Location (UCSC)	Chr 4: 77.51 – 77.61 Mb	Chr 5: 95.96 – 95.96 Mb
PubMed search	[1]	[2]

chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.

Function

CXCL13 is a small cytokine belonging to the CXC chemokine family. As its name suggests, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.

In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or T_FH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.