DUSP19

Dual specificity phosphatase 19
250px Mitogen-activated Protein Kinase Phosphatase, SKRP1. PDB 3s4e
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3S4E
Identifiers
Symbols	DUSP19 ; DUSP17; LMWDSP3; SKRP1; TS-DSP1
External IDs	OMIM: 611437 MGI: 1915332 HomoloGene: 41565 GeneCards: DUSP19 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein kinase inhibitor activity • MAP-kinase scaffold activity • protein binding • protein tyrosine/threonine phosphatase activity • JUN kinase phosphatase activity • protein kinase activator activity • mitogen-activated protein kinase kinase kinase binding Cellular component • cytoplasm Biological process • inactivation of MAPK activity • negative regulation of protein kinase activity • protein dephosphorylation • JNK cascade • activation of protein kinase activity • peptidyl-tyrosine dephosphorylation • positive regulation of MAPK cascade • positive regulation of JUN kinase activity • negative regulation of JUN kinase activity • positive regulation of protein kinase activity • negative regulation of JNK cascade • positive regulation of JNK cascade • negative regulation of cyclin-dependent protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE DUSP19 gnf1h03972 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	142679	68082
Ensembl	ENSG00000162999	ENSMUSG00000027001
UniProt	Q8WTR2	n/a
RefSeq (mRNA)	NM_001142314	NM_024438
RefSeq (protein)	NP_001135786	NP_077758
Location (UCSC)	Chr 2: 183.08 – 183.1 Mb	Chr 2: 80.62 – 80.63 Mb
PubMed search	[1]	[2]

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.

Interactions

DUSP19 has been shown to interact with ASK1 and MAP2K7.