SSH3

Slingshot protein phosphatase 3
Identifiers
Symbols	SSH3 ; SSH3L
External IDs	OMIM: 606780 MGI: 2683546 HomoloGene: 32372 GeneCards: SSH3 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • DNA binding • actin binding • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • nucleus • cytoplasm • cytoskeleton Biological process • protein dephosphorylation • regulation of actin polymerization or depolymerization • regulation of lamellipodium assembly • peptidyl-tyrosine dephosphorylation • regulation of axonogenesis Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SSH3 219241 x at tn.png
File:PBB GE SSH3 219919 s at tn.png
File:PBB GE SSH3 51192 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54961	245857
Ensembl	ENSG00000172830	ENSMUSG00000034616
UniProt	Q8TE77	Q8K330
RefSeq (mRNA)	NM_017857	NM_198113
RefSeq (protein)	NP_060327	NP_932781
Location (UCSC)	Chr 11: 67.3 – 67.31 Mb	Chr 19: 4.26 – 4.27 Mb
PubMed search	[1]	[2]

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]