EIF3D

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Eukaryotic translation initiation factor 3 subunit D is a protein that in humans is encoded by the EIF3D gene.[1][2]

Function

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.[2]

Interactions

EIF3D has been shown to interact with PHLDA1[3] and EIF3A.[4][5][6]

See also

References

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Further reading

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