Interleukin-36

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Interleukin-36 also known as IL-36 is a cytokine that predominantly acts on naive CD4+ T cells via the IL-36 receptor. It is known to activate NF-κB and mitogen-activated protein kinases to play a role in skin pathology.[1] It has also been found to activate T cell proliferation and release of IL-2.[2]

In humans, there are three distinct genes, IL36A, IL36B, and IL36G.

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