Lecithin—cholesterol acyltransferase

Lecithin-cholesterol acyltransferase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4X96
Identifiers
Symbol	LCAT
External IDs	OMIM: 606967 MGI: 96755 HomoloGene: 68042 ChEMBL: 5942 GeneCards: LCAT Gene
EC number	2.3.1.43
Gene ontology Molecular function • phosphatidylcholine-sterol O-acyltransferase activity • phospholipase A2 activity • protein binding • apolipoprotein A-I binding Cellular component • extracellular region • extracellular space • high-density lipoprotein particle • extracellular exosome Biological process • phospholipid metabolic process • phosphatidylcholine biosynthetic process • cholesterol metabolic process • cholesterol transport • very-low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling • cholesterol esterification • lipoprotein metabolic process • lipoprotein biosynthetic process • cholesterol homeostasis • reverse cholesterol transport • small molecule metabolic process • response to copper ion • response to glucocorticoid • regulation of high-density lipoprotein particle assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3931	16816
Ensembl	ENSG00000213398	ENSMUSG00000035237
UniProt	P04180	P16301
RefSeq (mRNA)	NM_000229	NM_008490
RefSeq (protein)	NP_000220	NP_032516
Location (UCSC)	Chr 16: 67.94 – 67.94 Mb	Chr 8: 105.94 – 105.94 Mb
PubMed search	[1]	[2]

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|px|alt=Statin Pathway edit]]

File:StatinPathway_WP430.png

Statin Pathway edit

See also

• Lecithin cholesterol acyltransferase deficiency
• Acyl-CoA:cholesterol acyltransferase (ACAT)

External links

• Lecithin Cholesterol Acyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)