MCM3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.[1]
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.[2]
Interactions
MCM3 has been shown to interact with:
- CDC45-related protein,[3]
- CDC6,[4][5]
- DBF4,[3]
- MCM2[3]
- MCM3AP,[6][7][8]
- MCM5,[3][9]
- MCM7,[3][4][10][11]
- ORC4L,[3] and
- ORC5L.[3]
See also
References
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