Maleylacetoacetate isomerase
| maleylacetoacetate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.2.1.2 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a maleylacetoacetate isomerase (EC 5.2.1.2) is an enzyme that catalyzes the chemical reaction
- 4-maleylacetoacetate
4-fumarylacetoacetate
Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.
References
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