Mitratapide

Mitratapide
	File:Mitratapide.svg
Systematic (IUPAC) name
	2-[(2R)-Butan-2-yl]-4-[4-[4-[4-[[(2S,4R)-2-(4-chlorophenyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
Clinical data
Trade names	Yarvitan
Identifiers
CAS Number	179602-65-4
ATCvet code	QA08AB90 (WHO)
PubChem	CID: 213047
ChemSpider	184740
UNII	FVW7T75XP4
Synonyms	Mitratapid; R103757
Chemical data
Formula	C36H41ClN8O4S
Molecular mass	717.28 g/mol
	SMILES CC[C@@H](C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@@H]5CO[C@@](O5)(CSC6=NN=CN6C)C7=CC=C(C=C7)Cl ;
	InChI InChI=1S/C36H41ClN8O4S/c1-4-26(2)45-35(46)44(25-39-45)31-11-9-29(10-12-31)42-17-19-43(20-18-42)30-13-15-32(16-14-30)47-21-33-22-48-36(49-33,27-5-7-28(37)8-6-27)23-50-34-40-38-24-41(34)3/h5-16,24-26,33H,4,17-23H2,1-3H3/t26-,33-,36-/m1/s1 ; Key:HQSRVYUCBOCBLY-XOOFNSLWSA-N ;

Mitratapide is a veterinary drug for the treatment of overweight and obese dogs sold under the brand name Yarvitan. Its mechanism of action involves inhibition of microsomal triglyceride transfer protein (MTP) which is responsible for the absorption of dietary lipids.^[1] Clinical study also suggests that mitratapide may help to reverse insulin resistance in dogs.^[2]

The drug was developed by Janssen Pharmaceutica and is chemically related to the antifungal drugs such as itraconazole which were also developed by Janssen.

References

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