Ciclazindol

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Ciclazindol
Ciclazindol structure.svg
Systematic (IUPAC) name
10-(3-chlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]indol-10-ol
Clinical data
Legal status
  •  ?
Routes of
administration		 Oral
Pharmacokinetic data
Metabolism Renal[1]
Biological half-life ~32 hours[1]
Excretion Urine, feces[1]
Identifiers
CAS Number 37751-39-6
ATC code none
PubChem CID: 37825
ChemSpider 34683
UNII Y3I9520J7P YesY
KEGG D03486
ChEMBL CHEMBL1192491
Chemical data
Formula C17H15ClN2O
Molecular mass 298.77 g/mol
  • Clc1cccc(c1)C3(O)c4c(N2\C3=N/CCC2)cccc4

Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed.[2][3] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.[2][4] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor.[4][5][6] As suggested by its local anesthetic properties,[5] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[7][8]

See also

References

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