Dacemazine

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Dacemazine
File:Dacemazine.svg
Systematic (IUPAC) name
2-dimethylamino-1-phenothiazin-10-ylethanone
Identifiers
CAS Number 518-61-6 N
ATC code none
PubChem CID: 68846
ChemSpider 62079 YesY
UNII 88D34UY0QI N
ChEMBL CHEMBL2107547 N
Chemical data
Formula C16H16N2OS
Molecular mass 284.376 g/mol
  • O=C(N1c3c(Sc2c1cccc2)cccc3)CN(C)C
  • InChI=1S/C16H16N2OS/c1-17(2)11-16(19)18-12-7-3-5-9-14(12)20-15-10-6-4-8-13(15)18/h3-10H,11H2,1-2H3 YesY
  • Key:HKUCYAHWPVLPFN-UHFFFAOYSA-N YesY
 NYesY (what is this?)

Dacemazine (INN, also known as Ahistan and Histantine)[1] is a phenothiazine derivative which acts as an histamine antagonist at the H1 subtype. First described in 1951, it was never marketed as a drug on its own, although a combination of dacemazine and di-tert-butylnaphthalenesulfonate was sold as an antispasmodic and antitussive under the trade name Codopectyl.[1] It was also assessed as a possible anticancer drug.[2]

References

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  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found. Retrieved on August 2, 2008 through Google Book Search.
  2. ↑ Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C. The anticarcinogenic effect of dimethylaminoacetyl-phentiazide (ahistan). Kiserletes Orvostudomany. 1952 Aug;4(4):260-2. PMID 13023855
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